Gold-catalyzed three-component coupling: oxidative oxyarylation of alkenes.

نویسندگان

  • Asa D Melhado
  • William E Brenzovich
  • Aaron D Lackner
  • F Dean Toste
چکیده

The three-component coupling of terminal alkenes with arylboronic acids and oxygen nucleophiles is described. The reaction employs a binuclear gold(I) bromide as a catalyst and Selectfluor reagent as the stoichiometric oxidant. Alcohols, carboxylic acids, and water can be employed as oxygen nucleophiles, thus providing an efficient entry into beta-aryl ethers, esters, and alcohols from alkenes.

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عنوان ژورنال:
  • Journal of the American Chemical Society

دوره 132 26  شماره 

صفحات  -

تاریخ انتشار 2010